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Literature summary extracted from

  • Zeeuwen, P.L.; Ishida-Yamamoto, A.; van Vlijmen-Willems, I.M.; Cheng, T.; Bergers, M.; Iizuka, H.; Schalkwijk, J.
    Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation (2006), J. Invest. Dermatol., 127, 120-128.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.43 cystatin M/E regulatory role, two distinct binding sites for cysteine proteases of the C1 peptidase family, the endogenous inhibitor is co-localized with the enzyme in lamellar granules and corneodesmosomes Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.43 additional information Homo sapiens the enzyme and inhibitor cystatin M/E are involved in regulation of epidermal differentiation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.43 epithelial cell
-
 Homo sapiens
-
3.4.22.43 hair follicle localization of the enzyme in the root sheets of the hair follicle Homo sapiens
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3.4.22.43 stratum corneum in extracellular space associated to corneodesmosomes, co-localization of the enzyme and inhibitor cystatin M/E Homo sapiens
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3.4.22.43 stratum granulosum co-localization of the enzyme and inhibitor cystatin M/E, which are separately transported within lamellar granules Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.43 additional information the enzyme and inhibitor cystatin M/E are involved in regulation of epidermal differentiation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.43 CTSV
-
 Homo sapiens